Journal: Materials Today Bio

Article Title: Genetically engineered bio-composite mediated dual-modality imaging-guided synergistic chemo-FUAS for tumor therapy

doi: 10.1016/j.mtbio.2025.101928

Figure Lengend Snippet: Schematic illustration of multifunctional bio-composite for anti-tumor therapy with synergistic FUAS (a) The construction of GVs- Ec @p/D and injected it intravenously into mice. (b) Upon intravenous injection, the obtained GVs- Ec @p/D in the tumor target area for enhancing FUAS combined with chemotherapy. (c) Guidance of dual-modality imaging with the irradiation of FUAS.

Article Snippet: Synergistic agents (SAs) can enhance the ablation efficiency to improve cancer therapy, has attracted increasing attention.

Techniques: Injection, Imaging, Irradiation

Journal: Materials Today Bio

Article Title: Genetically engineered bio-composite mediated dual-modality imaging-guided synergistic chemo-FUAS for tumor therapy

doi: 10.1016/j.mtbio.2025.101928

Figure Lengend Snippet: Synergistic effect of GVs- Ec @p/D by FUAS. ( a ) Representative photographs of ablated bovine livers after FUAS irradiation. The red dotted circle marks the coagulative necrosis of bovine livers. ( b ) Quantitative analysis of the gray value of bovine livers after FUAS irradiation (n = 3 , ∗∗∗∗ p < 0.0001). ( c ) Schematic diagram of the treatment process of FUAS. ( d ) Quantitative analysis of necrotic volume after FUAS ablation of bovine livers (n = 3, ∗∗∗∗ p < 0.0001). ( e ) Coagulative necrosis of tumors by TTC staining after FUAS, the necrotic tissue appears gray and the normal tumor tissue is red (yellow dotted circle marks the necrotic tissue). ( f ) The gray values of tumor tissues in each group after FUAS (n = 5, ∗∗ p < 0.01, -∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001). ( g ) In vivo USI of tumor tissues before and after FUAS ablation in different groups. The yellow dotted circle marks the tumor nodules. ( h ) The coagulative necrosis of tumor tissues in each group after FUAS (n = 5, ∗∗∗∗ p < 0.0001). ( i ) The EEF of tumor tissues in each group after FUAS (n = 5, ∗∗∗ p < 0.001, -∗∗∗∗ p < 0.0001). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Article Snippet: Synergistic agents (SAs) can enhance the ablation efficiency to improve cancer therapy, has attracted increasing attention.

Techniques: Irradiation, Staining, In Vivo

Journal: Materials Today Bio

Article Title: Genetically engineered bio-composite mediated dual-modality imaging-guided synergistic chemo-FUAS for tumor therapy

doi: 10.1016/j.mtbio.2025.101928

Figure Lengend Snippet: In vivo synergistic chemo-FUAS therapy efficacy. ( a ) The protocol of the treatment regimen. ( b )Photos of tumors at the 16th day after treatment. ( c ) Relative tumor volume of different groups (n = 5, ∗∗∗∗ P < 0.0001). ( d ) Tumor weight on the 16th day (n = 5, ∗∗ P < 0.01, ∗∗∗ P < 0.001, ∗∗∗∗ P < 0.0001). The survival curves ( e ) and body weight ( f ) of mice in each group (n = 5). ( g ) Optical microscope images of tumor sections from each group were stained for H&E staining, PCNA, and TUNEL testing. Scale bar: 100 μm.

Article Snippet: Synergistic agents (SAs) can enhance the ablation efficiency to improve cancer therapy, has attracted increasing attention.

Techniques: In Vivo, Microscopy, Staining, TUNEL Assay